|University of California, Irvine (UCI) – Mobley Lab ||
September 2016 – Present
| Claremont McKenna College (CMC) ||Sept. 2011 – May 2015|
Wych, David C., et al. “Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein.” Structural Dynamics 6.6 (2019): 064704.
Published: December 2019
Citations: 2 (Google Scholar)
Not peer reviewed:
|Wych, David C., Yun “Lyna” Luo. “Molecular Dynamics Simulation Study of PTEN Binding to Calpain Isoforms.” CMC Senior Thesis.|| |
Molecular Dynamics Simulations of Protein Crystals for Water Structure Prediction and Forcefield Development
|Molecular Dynamics Simulations of Protein X-Ray Crystallographic Diffuse Scattering |
Non-negative Matrix Factorization for Structural Dynamics Clustering of Electron Density Trajectories
|Graduate Student Researcher |
December 2016 – Present
|CNLS Virtual Summer Internship Program|
June 2020 – August 2020
|Graduate Student Assistant (GSA) ||January 2019 – August 2019|
|Applied Machine Learning (AML) Summer Fellow |
June 2018 – August 2018
|Undergraduate Student Researcher |
October 2014 – July 2015
|REU Summer Researcher|
June 2014 – August 2014
Honors and Awards
|Fellowship to attend the 2018 Applied Machine Learning Summer School||August 2018|
|Fellowship to attend the 2020 CNLS Summer Program at LANL||June 2020|
| Instructor – Physical Biochemistry (PHRMSCI 171) |
Fall 2019 and 2020
Research Focus, Interest Areas, and Relevant Skills
- Primarily focused on the study of diffuse (continuous) scattering in protein X-ray crystallography, the non-Bragg scattering associated with correlated dynamics.
- More recently focused on electron density analysis using crystalline MD simulations for prediction of water structure and MD forcefield improvement.
- Experienced in MD simulation using GROMACS, AMBER, and auxiliary software: Python, MdTraj, OpenEye tools, cctbx, DIALS, Lunus, Phenix, C, shell scripting, and OpenMP/MPI high-performance parallel computing.
- Cooking, music, mathematics, dog training, and Greek mythology for fun.