Education
Graduate:
University of California, Irvine (UCI) – Mobley Lab
|
September 2016 – Present |
Undergraduate
Claremont McKenna College (CMC)
| Sept. 2011 – May 2015 |
Publications
Peer reviewed:
Wych, David C., et al. “Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein.” Structural Dynamics 6.6 (2019): 064704.
| Published: December 2019 Citations: 2 (Google Scholar) |
Not peer reviewed:
Wych, David C., Yun “Lyna” Luo. “Molecular Dynamics Simulation Study of PTEN Binding to Calpain Isoforms.” CMC Senior Thesis. | May 2015 |
Presentations
Molecular Dynamics Simulations of Protein Crystals for Water Structure Prediction and Forcefield Development
| August 2020 |
Molecular Dynamics Simulations of Protein X-Ray Crystallographic Diffuse Scattering
| July 2019 |
Non-negative Matrix Factorization for Structural Dynamics Clustering of Electron Density Trajectories
| August 2018 |
Research Experience
Graduate Student Researcher
| December 2016 – Present |
CNLS Virtual Summer Internship Program
| June 2020 – August 2020 |
Graduate Student Assistant (GSA)
| January 2019 – August 2019 |
Applied Machine Learning (AML) Summer Fellow
| June 2018 – August 2018 |
Undergraduate Student Researcher
| October 2014 – July 2015 |
REU Summer Researcher
| June 2014 – August 2014 |
Honors and Awards
Fellowship to attend the 2018 Applied Machine Learning Summer School | August 2018 |
Fellowship to attend the 2020 CNLS Summer Program at LANL | June 2020 |
Instruction
Instructor – Physical Biochemistry (PHRMSCI 171)
| Fall 2019 and 2020 |
Research Focus, Interest Areas, and Relevant Skills
- Primarily focused on the study of diffuse (continuous) scattering in protein X-ray crystallography, the non-Bragg scattering associated with correlated dynamics.
- More recently focused on electron density analysis using crystalline MD simulations for prediction of water structure and MD forcefield improvement.
- Experienced in MD simulation using GROMACS, AMBER, and auxiliary software: Python, MdTraj, OpenEye tools, cctbx, DIALS, Lunus, Phenix, C, shell scripting, and OpenMP/MPI high-performance parallel computing.
- Cooking, music, mathematics, dog training, and Greek mythology for fun.